2,3-二氢-1,4-苯并二氧甲醇合成路线 （共 5 条）
反应条件
1: With sodium tetrahydroborate in ethanol T=0 - 20°C; 1 h; 2: With water in ethanol
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 43 ;
反应条件
potassium borohydride; lithium chloride 0.1 h; microwave irradiation;
参考文献
Feng; Liu; Dai; Yang; Tu
Synthetic Communications, 2001 , vol. 31, # 12 p. 1875 - 1877
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-10 - 20°C; 4 h; Inert atmosphere;
参考文献
Marugan, Juan J.; Zheng, Wei; Motabar, Omid; Southall, Noel; Goldin, Ehud; Westbroek, Wendy; Stubblefield, Barbara K.; Sidransky, Ellen; Aungst, Ronald A.; Lea, Wendy A.; Simeonov, Anton; Leister, William; Austin, Christopher P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 1033 - 1058
反应条件
1: caesium carbonate / N,N-dimethyl-formamide 2: NaOH; LiAlH4 / tetrahydrofuran; water View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; 24 h;
参考文献
EXELIXIS, INC.; CHAN, Wai, Ki, Vicky; DU, Hongwang; KEARNEY, Patrick; KOLTUN, Elena, S.; NACHTIGALL, Jason, August; NOSON, Kevin; PACK, Michael; RICHARDS, Steven, James
Patent: WO2010/91104 A1, 2010 ;
Location in patent: Page/Page column 51 ;
