2,3-二羟基-4-甲基苯甲酸合成路线 （共 9 条）
反应条件
potassium carbonate
unter Druck;
参考文献
Wessely et al.
Monatshefte fuer Chemie, 1950 , vol. 81, p. 1071,1083
反应条件
2,6-dihydroxybenzoatedecarboxylase fromRhizobium sp in aq. phosphate buffer
T=30°C; Kolbe-Schmidt Synthesis; 24 h; Enzymatic reaction; regioselective reaction;
参考文献
Wuensch, Christiane; Gross, Johannes; Steinkellner, Georg; Lyskowski, Andrzej; Gruber, Karl; Glueck, Silvia M.; Faber, Kurt
RSC Advances, 2014 , vol. 4, # 19 p. 9673 - 9679
反应条件
potassium carbonate
T=150 - 175°C; P=29420.3 - 36775.4 Torr;
参考文献
Wessely et al.
Monatshefte fuer Chemie, 1950 , vol. 81, p. 1071,1083
反应条件
trimethylsilyl iodide in dichloromethane
23 h; Reflux;
参考文献
Clapham, Kate M.; Rennison, Tommy; Jones, Gavin; Craven, Faye; Bardos, Julia; Golding, Bernard T.; Griffin, Roger J.; Haggerty, Karen; Hardcastle, Ian R.; Thommes, Pia; Ting, Attilla; Cano, Celine
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 33 p. 6747 - 6757
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate / 1,4-dioxane; dichloromethane / 2 h / 120 °C / Microwave irradiation
2: trimethylsilyl iodide / dichloromethane / 23 h / Reflux
View Scheme
参考文献
Clapham, Kate M.; Rennison, Tommy; Jones, Gavin; Craven, Faye; Bardos, Julia; Golding, Bernard T.; Griffin, Roger J.; Haggerty, Karen; Hardcastle, Ian R.; Thommes, Pia; Ting, Attilla; Cano, Celine
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 33 p. 6747 - 6757
反应条件
1: H2SO4
2: LiAlH4
3: H2 / Pd-C / ethanol
View Scheme
参考文献
Baines,M.W. et al.
J. Med. Chem., 1965 , vol. 8, p. 81 - 90
反应条件
sodium hydroxide in water
T=45°C; 4 h;
参考文献
Mills, Frank D.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1597 - 1600
反应条件
sodium hydroxide
1) acetone, 24 h, reflux; 2) reflux, 10 h, water; Yield given. Multistep reaction;
参考文献
Ecker,D.J.; Loomis,L.D.; Cass,M.E.
Journal of the American Chemical Society, 1988 , vol. 110, p. 2457
反应条件
1: 2) NaOH / 1) acetone, 24 h, reflux; 2) reflux, 10 h, water
2: 66 percent / thionyl chloride / benzene; dimethylformamide / 10 h / Heating
View Scheme
参考文献
Mills, Frank D.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1597 - 1600
