5-氨基-2-硝基三氟甲苯合成路线 （共 43 条）
反应条件
potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
sodium hydroxide T=25°C;
参考文献
Schering Corporation
Patent: US4302599 A1, 1981 ;
反应条件
ammonia in hexane; water; ethyl acetate
参考文献
Pfizer Inc.
Patent: US4728653 A1, 1988 ;
反应条件
1: With 5-(2-hydroxyethyl)-4-methyl-3-(phenylmethyl)thiazolium chloride; tert-butyl alcohol in tetrahydrofuran T=20°C; 0.0833333 h; Inert atmosphere; 2: With sodium t-butanolate in tetrahydrofuran T=20°C; 12 h; Inert atmosphere; chemoselective reaction;
参考文献
Burnley, James; Carbone, Giorgio; Moses, John E.
Synlett, 2013 , vol. 24, # 5 art. no. ST-2013-D0038-L, p. 652 - 656
反应条件
sodium hydroxide in N-methyl-acetamide; methanol; ammonia; water
参考文献
Bayer Aktiengesellschaft
Patent: US5262539 A1, 1993 ;
反应条件
2,4,6-trichlorosulfenamide; potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
sulfuric acid; nitric acid und Erwaermen des Reaktionsprodukts mit aethanol.Natronlauge;
参考文献
Forbes,E.J. et al.
Tetrahedron, 1960 , vol. 8, p. 67 - 72
反应条件
Rhodotorula mucilaginosa (ATCC 20129) in N,N-dimethyl-formamide T=20°C; 336 h; Physiological pHMicrobiological reaction;
参考文献
Herath, Wimal; Khan, Ikhlas Ahmad
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 4 p. 562 - 564
参考文献
Forbes,E.J. et al.
Tetrahedron, 1960 , vol. 8, p. 67 - 72
反应条件
sulfuric acid; nitric acid
参考文献
Rouche
Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1927 , vol. <5> 13, p. 349
Chem. Zentralbl., 1927 , vol. 98, # II p. 1817
