4-氯-3,5-二硝基三氟甲苯合成路线 （共 44 条）
参考文献
Eli Lilly and Company
Patent: US4024142 A1, 1977 ;
反应条件
sulfuric acid; sulfur trioxide; nitric acid T=100 - 115°C; 2 h;
参考文献
Zhao, Ting-Ting; Lu, Xiang; Yang, Xian-Hui; Wang, Li-Ming; Li, Xi; Wang, Zhong-Chang; Gong, Hai-Bin; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3233 - 3241
反应条件
sulfuric acid; sulfur trioxide; nitric acid in water
参考文献
GAF Corporation
Patent: US4096195 A1, 1978 ;
反应条件
sulfur trioxide; nitric acid in water
参考文献
Montedison S.p.A.
Patent: US4110405 A1, 1978 ;
反应条件
1: sulfuric acid; sulfur trioxide; nitric acid / 3 h / 50 - 70 °C 2: sulfuric acid; sulfur trioxide; nitric acid / 2 h / 100 - 115 °C View Scheme
参考文献
Zhao, Ting-Ting; Lu, Xiang; Yang, Xian-Hui; Wang, Li-Ming; Li, Xi; Wang, Zhong-Chang; Gong, Hai-Bin; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3233 - 3241
反应条件
1: 69 percent / NaI, glacial acetic acid / acetone / 24 h / 63 - 65 °C 2: 77 percent / KF, o-phthaloyl dichloride / tetrahydrothiophene 1,1-dioxide / 24 h / 180 - 200 °C 3: 40 percent / KNO2 / dimethylformamide / 20 h / 130 - 140 °C 4: KNO2 / dimethylformamide / 20 h / 130 - 140 °C View Scheme
参考文献
Khalfina; Rogozhnikova; Vlasov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 9 p. 1325 - 1331
反应条件
sodium hydroxide in dimethyl sulfoxide
参考文献
Chen, Mei-Jin; Chi, Ching-Sung; Chen, Qing-Yun
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 54, # 1/4 p. 87 - 93
反应条件
triethylamine in N,N-dimethyl-formamide 2.5 h; Ambient temperature;
参考文献
Chen, Mei-Jin; Chi, Ching-Sung; Chen, Qing-Yun
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 54, # 1/4 p. 87 - 93
反应条件
oxygen; triethylamine in N,N-dimethyl-formamide 1.5 h; Ambient temperature;
参考文献
Chen, Mei-Jin; Chi, Ching-Sung; Chen, Qing-Yun
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 54, # 1/4 p. 87 - 93
反应条件
tetreamethyl ammonium hydroxide in water; dimethyl sulfoxide T=25°C; various solvents ratios, various adducts; Rate constant;
参考文献
Crampton, Michael R.; Greenhalgh, Colin
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 187 - 192
