4-氯-3,5-二硝基三氟甲苯合成路线 （共 44 条）
反应条件
potassium hydroxide in water; N,N-dimethyl-formamide
参考文献
D'Amico,J.J. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 600 - 602
参考文献
Tolstikova, Tatyana G.; Pavlova, Alla V.; Morozova, Ekaterina A.; Khomenko, Tatyana M.; Volcho, Konstantin P.; Salakhutdinov, Nariman F.
Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 513 - 516
反应条件
1: indole With methyl-magnesium iodide; zinc(II) chloride in diethyl ether
T=20°C; 0.833333 h;
2: 1-chloro-2,6-dinitro-4-(trifluoromethyl)benzene in diethyl ether
T=20°C; 4 h;
参考文献
Al-Khashashneh, Adel M.; El-Abadelah, Mustafa M.; Boese, Roland
Heterocycles, 2003 , vol. 60, # 1 p. 73 - 87
反应条件
potassium fluoride in acetonitrile
1.) -15 deg C, 4 h, 2.) r.t., overnight;
参考文献
Clark, James H.; Tavener, Stewart J.
Journal of Fluorine Chemistry, 1997 , vol. 85, # 2 p. 169 - 172
