2-硝基-5-氟苯甲酸甲酯合成路线 （共 10 条）
反应条件
thionyl chloride in methanol; water
参考文献
Takeda Chemical Industries, Inc.
Patent: US6407116 B1, 2002 ;
反应条件
potassium carbonate in acetone T=20°C; 50 h; Reflux;
参考文献
BIOLIPOX AB
Patent: WO2009/127822 A2, 2009 ;
Location in patent: Page/Page column 79 ;
WO 2009/127822 A2
反应条件
in methanol; hexane; toluene 1.66667 h;
参考文献
Life Technologies Corporation; Ma, Zhaochun; Mullah, Khairuzzaman Bashar; Eason, Robert G.
Patent: US8658776 B2, 2014 ;
Location in patent: Page/Page column 17; 34 ;
反应条件
thionyl chloride Cooling with iceReflux;
参考文献
Dams, Gery Karel Julia; Vereycken, Inge; Van Acker, Koenraad Lodewijk August; Gustin, Emmanuel Marie Paul Ernest; Verschueren, Wim Gaston; Ohagen, Asa Catrine
Patent: US2010/280268 A1, 2010 ;
Location in patent: Page/Page column 57 ;
反应条件
sulfuric acid; potassium nitrate
参考文献
Rohm and Haas Company
Patent: US4259510 A1, 1981 ;
参考文献
Fosdick; Blackwell
Journal of the American Chemical Society, 1944 , vol. 66, p. 1165
反应条件
hydrogen; palladium on activated carbon in methanol P=760.051 Torr; 120 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/28474 A2, 2005 ;
Location in patent: Page/Page column 201-202 ;
WO 2005/028474 A2
反应条件
potassium carbonate; dimethyl sulfoxide
参考文献
Rohm and Haas Company
Patent: US4259510 A1, 1981 ;
反应条件
potassium carbonate in dimethyl sulfoxide
T=60°C; 8 h; Autoclave;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: WO2008/28688 A2, 2008 ;
Location in patent: Page/Page column 129 ;
反应条件
in dimethyl sulfoxide
T=60°C; 2.25 h;
参考文献
Cheruvallath, Zacharia; Feng, Jun; Guntupalli, Prasuna; Gwaltney, Stephen L.; Kaldor, Stephen W.; Miura, Joanne; Sabat, Mark; Tang, Mingnam; Wolgast, Beverly
Patent: US2007/213349 A1, 2007 ;
Location in patent: Page/Page column 73; 74 ;
US 20070213349 A1
