反应条件
1: 2,4-dichloro-5-trifluoromethyl-pyrimidine With zinc(II) chloride in diethyl ether; dichloromethane; tert-butyl alcohol
T=-5°C; 1 h;
2: 4-methoxy-benzylamine With triethylamine in diethyl ether; dichloromethane; tert-butyl alcohol
T=-5 - 20°C; 16 h;
参考文献
Walker, Daniel P.; Christopher Bi; Kalgutkar, Amit S.; Bauman, Jonathan N.; Zhao, Sabrina X.; Soglia, John R.; Aspnes, Gary E.; Kung, Daniel W.; Klug-McLeod, Jacquelyn; Zawistoski, Michael P.; McGlynn, Molly A.; Oliver, Robert; Dunn, Matthew; Li, Jian-Cheng; Richter, Daniel T.; Cooper, Beth A.; Kath, John C.; Hulford, Catherine A.; Autry, Christopher L.; Luzzio, Michael J.; Ung, Ethan J.; Roberts, W. Gregory; Bonnette, Peter C.; Buckbinder, Leonard; Mistry, Anil; Griffor, Matthew C.; Han, Seungil; Guzman-Perez, Angel
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6071 - 6077