2,4-二氯嘧啶合成路线

Wang, Yi-Feng; Liu, Wei-Min; Zhu, You-Quan; Zou, Xiao-Mao; Hu, Fang-Zhong; Yang, Hua-Zheng
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 5 p. 1275 - 1280

3934-20-12,4-二氯嘧啶+

7727-37-9氮气

52476-87-62-氯-4-肼基嘧啶

参考文献

VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/46120 A2, 2004 ;
Location in patent: Page 162 ;
WO 2004/046120 A2

3934-20-12,4-二氯嘧啶

1158984-54-3+

52476-87-62-氯-4-肼基嘧啶

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/68652 A1, 2009 ;
Location in patent: Page/Page column 30 ;

3934-20-12,4-二氯嘧啶

51953-18-54-羟基嘧啶

参考文献

Wheeler
Journal of Biological Chemistry, 1907 , vol. 3, p. 288
Chem. Zentralbl., 1907 , vol. 78, # II p. 1529

557-21-1氰化锌+

3934-20-12,4-二氯嘧啶

75833-38-42-氯-4-氰基嘧啶

参考文献

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; DISALVO, Darren; FANDRICK, Daniel Robert; HARCKEN, Christian; KUZMICH, Daniel; LEE, Thomas Wai-Ho; LIU, Pingrong; LORD, John; MAO, Can; NEU, Jochen; RAUDENBUSH, Brian Christopher; RAZAVI, Hossein; REEVES, Jonathan Timothy; SONG, Jinhua, J.; SWINAMER, Alan, David; TAN, Zhulin
Patent: WO2010/36632 A1, 2010 ;
Location in patent: Page/Page column 220; 221 ;

3934-20-12,4-二氯嘧啶+

100-51-6苯甲醇

108381-28-84-苄氧基-2-氯嘧啶

参考文献

VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
Location in patent: Page/Page column 107 ;
WO 2011/019405 A1