1: acetylacetone With potassium carbonate in N,N-dimethyl-formamide T=20°C; 1 h; 2: phenyl isothiocyanate in N,N-dimethyl-formamide T=20°C; 2 h; 3: ethyl bromoacetate With potassium carbonate in N,N-dimethyl-formamide T=20°C; Dieckmann type cyclisation; 4 h;

potassium carbonate in ethanol

1.1: K2CO3 / dimethylformamide / 1 h / 20 °C 1.2: dimethylformamide / 2 h / 20 °C 1.3: 96 percent / dimethylformamide / 4 h / 20 °C 2.1: 79 percent / K2CO3 / ethanol / 6 h / Heating View Scheme