5-(2-噻吩)-3-吡啶甲醇合成路线 （共 3 条）
反应条件
sodium acetate; pyridinium chlorochromate in dichloromethane T=20°C; 2 h;
参考文献
Shi; Wheelhouse; Sun; Hurley
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4509 - 4523
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in methanol; toluene
T=70°C; Suzuki coupling reaction; 20 h;
参考文献
Shi; Wheelhouse; Sun; Hurley
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4509 - 4523
反应条件
1: 29 percent / BH3*THF / tetrahydrofuran / 4 h / Heating
2: 65 percent / Pd(PPh3)4; aq. Na2CO3 / toluene; methanol / 20 h / 70 °C
View Scheme
参考文献
Shi; Wheelhouse; Sun; Hurley
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4509 - 4523
