5-氟-2-硝基苯甲酰氯合成路线 （共 16 条）
反应条件
1: 97 percent / triethylamine / CH2Cl2 / 5 h / 20 °C
2: 89 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: 96 percent / triethylamine / CH2Cl2 / 5 h / 20 °C
2: 98 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
3: 76 percent / AcOH; Fe dust / ethanol / 5 h / Heating
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: 97 percent / triethylamine / CH2Cl2 / 5 h / 20 °C
2: 89 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
3: 65 percent / AcOH; Fe dust / ethanol / 5 h / Heating
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
in tetrahydrofuran
T=0 - 20°C; 15 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2006/21454 A2, 2006 ;
Location in patent: Page/Page column 85; 86 ;
WO 2006/021454 A2
反应条件
1: ammonia / 1,2-dichloro-ethane / 20 °C
2: palladium 10 on activated carbon; hydrogen / methanol
3: sodium hydrogensulfite / N,N-dimethyl acetamide / 3 h / 150 °C
4: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0.5 h / 50 °C
View Scheme
参考文献
Hour, Mann-Jen; Yang, Jai-Sing; Chen, Tai-Lin; Chen, Kuan-Tin; Kuo, Sheng-Chu; Chung, Jing-Gung; Lu, Chi-Cheng; Chen, Chia-Yi; Chuang, Yi-Hsuan
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2709 - 2721
反应条件
2: platinum; ethanol / Hydrogenation
View Scheme
参考文献
Fosdick; Blackwell
Journal of the American Chemical Society, 1944 , vol. 66, p. 1165
