2-氨基-5-羟基苯甲酸合成路线 （共 51 条）
反应条件
2: alkali 3: concentrated hydrochloric acid View Scheme
参考文献
Friedlaender
Chemische Berichte, 1916 , vol. 49, p. 965
参考文献
Limpricht
Chemische Berichte, 1889 , vol. 22, p. 2907
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; Bao, Rudi
Patent: US2009/111772 A1, 2009 ;
Location in patent: Page/Page column 68-69 ;
US 20090111772 A1
反应条件
ethanol; sodium ethanolate; trimethylphenylammonium p-toluenesulfonate
参考文献
Rodionow; Fedorowa
Bulletin de la Societe Chimique de France, 1939 , vol. <5>6, p. 478,485
Z.obsch.Chim.Chem.Abstr., 1943 , vol. 13, p. 249,251
Z.obsch.Chim.Chem.Abstr., 1944 , p. 1507
反应条件
in tetrahydrofuran T=70°C; 3.5 h;
参考文献
Sawatzky, Edgar; Bukowczan, Jerzy; Decker, Michael
Tetrahedron Letters, 2014 , vol. 55, # 18 p. 2973 - 2976
反应条件
hydrogenchloride in 1,4-dioxane; toluene
参考文献
Eli Lilly and Company
Patent: US6313122 B1, 2001 ;
US 6313122 B1
反应条件
1: in 1,4-dioxane 2 h; Heating; 2: With oxalyl dichloride in 1,4-dioxane 1 h; Heating;
参考文献
Roos, Gregory H. P.; Dastlik, Kim A.
Heterocycles, 2003 , vol. 60, # 9 p. 2023 - 2044
反应条件
1: 2-Amino-5-hydroxy-benzoic acid; acetic anhydride Heating; 2: 3.4-diacetoxybenzaldehyde With toluene-4-sulfonic acid in toluene Heating; 3: With sodium salt of phosphorous acid Heating;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 51, # 3 p. 594 - 600
反应条件
methanol; potassium hydroxide; dicyclohexyl-carbodiimide 1.) pyridine, 24 h, 3.) room temperature, 24 h; Yield given. Multistep reaction;
参考文献
Phytochemistry, , vol. 47, # 6 p. 969 - 974
反应条件
sodium methylate in methanol
0.5 h; Heating;
参考文献
Hayakawa, Masahiko; Kaizawa, Hiroyuki; Moritomo, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-ichi; Parker, Peter; Workman, Paul; Waterfield, Mike
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6847 - 6858
