2-氨基-5-羟基苯甲酸合成路线 （共 51 条）
反应条件
1: 2-Amino-5-hydroxy-benzoic acid; acetic anhydride Heating;
2: para-Acetoxybenzaldehyde With toluene-4-sulfonic acid in toluene
Heating;
3: With sodium salt of phosphorous acid
Heating;
参考文献
Bratt, Katarina; Sunnerheim, Kerstin; Bryngelsson, Susanne; Fagerlund, Amelie; Engman, Lars; Andersson, Rolf E.; Dimberg, Lena H.
Journal of Agricultural and Food Chemistry, 2003 , vol. 51, # 3 p. 594 - 600
反应条件
1.1: potassium carbonate / tetrahydrofuran / 24 h / 50 °C
2.1: potassium carbonate / acetone / 4 h / Reflux
3.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 °C
3.2: 20 °C
4.1: tetrahydrofuran / -78 - 20 °C
5.1: 10 palladium on activated charcoal; hydrogen / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
Desrat, Sandy; Jean, Mickael; Van De Weghe, Pierre
Tetrahedron, 2011 , vol. 67, # 39 p. 7510 - 7516
反应条件
1: aqueous hydrochloric acid
2: acetic acid anhydride; sodium acetate
View Scheme
参考文献
Colonna
Gazzetta Chimica Italiana, 1939 , vol. 69, p. 684,687
反应条件
thionyl chloride in benzene
4 h; Reflux;
参考文献
Jahng, Katherine Chae; Kim, Seung Ill; Kim, Dong Hyeon; Seo, Chang Seob; Son, Jong-Keun; Lee, Seung Ho; Lee, Eung Seok; Jahng, Yurngdong
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 607 - 609
反应条件
1: 1,4-dioxane / 2 h / |Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / |Inert atmosphere
3: potassium hydroxide / methanol; water / 2 h / |Reflux
4: oxalyl dichloride / tetrahydrofuran / 2 h / |Reflux
5: 1 h / 2585.81 - 5171.62 Torr / |Microwave irradiation; |Heating
6: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
Darras, Fouad H.; Pockes, Steffen; Huang, Guozheng; Wehle, Sarah; Strasser, Andrea; Wittmann, Hans-Joachim; Nimczick, Martin; Sotriffer, Christoph A.; Decker, Michael
ACS Chemical Neuroscience, 2014 , vol. 5, # 3 p. 225 - 242
反应条件
1.1: sodium nitrite; hydrogenchloride / 0.5 h / 0 °C
1.2: 0.83 h / 0 - 90 °C
2.1: potassium carbonate / acetone / 5 h / |Reflux
View Scheme
参考文献
Aoyama, Atsushi; Endo-Umeda, Kaori; Kishida, Kenji; Ohgane, Kenji; Noguchi-Yachide, Tomomi; Aoyama, Hiroshi; Ishikawa, Minoru; Miyachi, Hiroyuki; Makishima, Makoto; Hashimoto, Yuichi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7360 - 7377
反应条件
1.1: NaNO2; aq. H2SO4 / 0 °C
1.2: 57 percent / KI / 90 °C
2.1: 100 percent / HCl / Heating
View Scheme
参考文献
Reed, Neal N; Delgado, Mercedes; Hereford, Kristina; Clapham, Bruce; Janda, Kim D
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 15 p. 2047 - 2049
反应条件
sulfuric acid; potassium iodide; sodium nitrite
参考文献
Muelbaier; Giannis
Angewandte Chemie - International Edition, 2001 , vol. 40, # 23 p. 4393 - 4394
反应条件
1: SOCl2 / -20 - 20 °C
2: 50 °C
3: acetone / 4 h
4: HCl / methanol / 1 h / Heating
5: aq. NaOH / methanol / 1 h / Heating
View Scheme
参考文献
Borza, Istvan; Kolok, Sandor; Galgoczy, Kornel; Gere, Aniko; Horvath, Csilla; Farkas, Sandor; Greiner, Istvan; Domany, Gyoergy
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 406 - 409
反应条件
1: 90 percent / NaNO2; H2SO4; KI
View Scheme
参考文献
Muelbaier; Giannis
Angewandte Chemie - International Edition, 2001 , vol. 40, # 23 p. 4393 - 4394
