2-氟-4-甲氧基苯甲酸合成路线 （共 18 条）
反应条件
hydrogenchloride; sodium hydroxide; Ag2O in water
参考文献
Wyeth
Patent: US2006/46968 A1, 2006 ;
Location in patent: Page/Page column 28-29 ;
反应条件
sodium hydroxide; bromine in water 2 h; Ambient temperature;
参考文献
Hartmann; Vom Orde; Schonenberger
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 73 - 78
反应条件
potassium hydroxide; ethanol in water 25 h; Heating;
参考文献
Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24
反应条件
potassium permanganate
参考文献
Bennett; Niemann
Journal of the American Chemical Society, 1950 , vol. 72, p. 1806
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 2 h / Ambient temperature 2: 1.) Br2, aq. NaOH / 1.) 10 deg C, 2.) dioxane, RT, 1 h View Scheme
参考文献
Gust, Ronald; Burgemeister, Thomas; Mannschreck, Albrecht; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2535 - 2544
反应条件
1: dimethyl sulfate; aqueous NaOH 2: aqueous KMnO4 View Scheme
参考文献
Bennett; Niemann
Journal of the American Chemical Society, 1950 , vol. 72, p. 1806
反应条件
1: platinum; ethanol / Hydrogenation 2: aqueous H2SO4; NaNO2 / anschliessendes Erhitzen 3: dimethyl sulfate; aqueous NaOH 4: aqueous KMnO4 View Scheme
参考文献
Bennett; Niemann
Journal of the American Chemical Society, 1950 , vol. 72, p. 1806
反应条件
1: aqueous H2SO4; NaNO2 / anschliessendes Erhitzen 2: dimethyl sulfate; aqueous NaOH 3: aqueous KMnO4 View Scheme
参考文献
Bennett; Niemann
Journal of the American Chemical Society, 1950 , vol. 72, p. 1806
反应条件
1: 61 percent / bromine / CHCl3 / 0.01 h 2: 1-methyl-2-pyrrolidinone / 2 h / 180 °C 3: sodium hydroxide / H2O / 60 h 4: 62 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating View Scheme
参考文献
Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24
反应条件
1: 1-methyl-2-pyrrolidinone / 2 h / 180 °C 2: sodium hydroxide / H2O / 60 h 3: 62 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating View Scheme
参考文献
Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24
