2-氟-4-甲氧基苯甲酸合成路线 (共 18 条)
反应条件
1: sodium hydroxide / H2O / 60 h 2: 62 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating View Scheme
参考文献
Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24
反应条件
1: LiAlH4 / diethyl ether / 1 h / Heating 2: HCl gas / benzene / 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 9 p. 2535 - 2544
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Heating;
参考文献
Gust, Ronald; Burgemeister, Thomas; Mannschreck, Albrecht; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2535 - 2544
反应条件
sulfuryl dichloride RefluxInert atmosphere;
参考文献
JOHANN WOLFGANG GOETHE-UNIVERSITÄT; GENKYOTEX SA; BRANDES, Ralf; SCHRÖDER, Katrin; PAGE, Patrick; LALEU, Benoît; GAGGINI, Francesca
Patent: WO2013/68972 A1, 2013 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 96.8 percent / DIPEA, diphenylphosphoryl azide / toluene / 16 h / Heating 2: 80.6 percent / HCl (gas) / methanol View Scheme
参考文献
Stadlwieser, Josef; Barbier, Pierre; Taylor, Sven
Helvetica Chimica Acta, 1998 , vol. 81, # 6 p. 1088 - 1094
反应条件
sulfuric acid T=0 - 65°C; 14 h;
参考文献
Japan Tobacco, Inc.
Patent: EP1992607 A1, 2008 ;
Location in patent: Page/Page column 87 ;
反应条件
sulfuric acid
5 h; Reflux;
参考文献
Chandrakantha; Shetty, Prakash; Nambiyar, Vijesh; Isloor, Nishitha; Isloor, Arun M.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 3 p. 1206 - 1210
反应条件
bromine; acetic acid
T=25 - 60°C;
参考文献
Matsuda, Koji; Ando, Koji; Ohki, Shigeji; Yamasaki, Takahiro; Hoshi, Jun-ichi
Patent: US2009/318702 A1, 2009 ;
Location in patent: Page/Page column 57 ;