1-氟-2,3-二甲氧基苯合成路线 （共 21 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 18 h;
参考文献
Eisai Co., Ltd.
Patent: EP1391451 A1, 2004 ;
Location in patent: Page 95 ;
反应条件
potassium carbonate in acetone 12 h; Heating;
参考文献
Adejare, Adeboye; Miller, Duane D.
Journal of Chemical Research, Miniprint, 1986 , # 1 p. 171 - 193
反应条件
in tetrahydrofuran; hexane; toluene
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4479901 A1, 1984 ;
反应条件
potassium carbonate in acetone 0.75 h; Heating;
参考文献
Ladd, David L.; Gaitanopoulos, Dimitri; Weinstock, Joseph
Synthetic Communications, 1985 , vol. 15, p. 61 - 70
反应条件
2: 88 percent / K2CO3 / acetone / 12 h / Heating View Scheme
参考文献
Ladd, David L.; Weinstock, Joseph
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 203 - 206
反应条件
1: 73 percent / m-chloro-perbenzoic acid / CH2Cl2 / Heating 2: 91 percent / K2CO3 / acetone / 0.75 h / Heating View Scheme
参考文献
Ladd, David L.; Gaitanopoulos, Dimitri; Weinstock, Joseph
Synthetic Communications, 1985 , vol. 15, p. 61 - 70
反应条件
potassium carbonate in acetone Reflux;
参考文献
Kiss, Laszlo E.; Ferreira, Humberto S.; Torrao, Leonel; Bonifacio, Maria Joao; Palma, P. Nuno; Soares-Da-Silva, Patricio; Learmonth, David A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3396 - 3411
反应条件
n-butyllithium; perchloryl fluoride 1.) ether, room temperature, 22 h, 2.) 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Peet, Norton P.; McCarthy, James R.; Sunder, Shyam; McCowan, Jefferson
Synthetic Communications, 1986 , vol. 16, # 12 p. 1551 - 1556
反应条件
water in acetonitrile Irradiationother fluoromethoxybenzenes; other solvents; Quantum yieldMechanism;
参考文献
Zhang, Guangzhong; Wan, Peter
Journal of the Chemical Society, Chemical Communications, 1994 , # 1 p. 19 - 20
反应条件
1: 81.8 percent / AlCl3 / 1,2-dichloro-ethane / 2.5 h / -20 - 20 °C 2: 62 percent / Br2 / CHCl3 / 2 h / Ambient temperature 3: 1.) diethylamine, 2.) conc. HCl / 1.) i-Pr-OH, RT, 6 h, 2.) i-PrOH View Scheme
参考文献
Stegmann, Hartmut B.; Deuschle, Gabriele; Schuler, Paul
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 3 p. 547 - 556
