1-氟-2,3-二甲氧基苯合成路线 （共 21 条）
反应条件
NbCl5 in 1,2-dichloro-ethane 1.5 h; Heating; Title compound not separated from byproducts;
参考文献
Sudo, Yukinori; Arai, Shigeru; Nishida, Atsushi
European Journal of Organic Chemistry, 2006 , # 3 p. 752 - 758
反应条件
aluminium trichloride; chlorobenzene
参考文献
Corse; Ingraham
Journal of Organic Chemistry, 1951 , vol. 16, p. 1345,1348
反应条件
hydrogenchloride in acetic acid T=20 - 25°C; 4.5 h;
参考文献
Ladd, David L.; Weinstock, Joseph
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 203 - 206
参考文献
Kaiser; Burger
Journal of the American Chemical Society, 1957 , vol. 79, p. 4365,4369
反应条件
in trifluoroacetic acid
Heating;
参考文献
Ladd, David L.; Gaitanopoulos, Dimitri; Weinstock, Joseph
Synthetic Communications, 1985 , vol. 15, p. 61 - 70
反应条件
1: 95 percent / HCl / acetic acid / 4.5 h / 20 - 25 °C
2: 92 percent / dimethylsulfoxide / 0.75 h
3: 76 percent / BH3 / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Ladd, David L.; Weinstock, Joseph
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 203 - 206
反应条件
1: 86 percent / HCl / acetic acid / 4 h
2: 87 percent / dimethylsulfoxide / 1.5 h
View Scheme
参考文献
Ladd, David L.; Weinstock, Joseph
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 203 - 206
反应条件
NbCl5 in 1,2-dichloro-ethane
1.5 h; Heating; Title compound not separated from byproducts;
参考文献
Sudo, Yukinori; Arai, Shigeru; Nishida, Atsushi
European Journal of Organic Chemistry, 2006 , # 3 p. 752 - 758
反应条件
1: 74 percent / TiCl4 / CH2Cl2 / 0 deg C, 0.5 h; RT, 4.5 h
2: 1.) BBr3
View Scheme
参考文献
Adejare, Adeboye; Gusovsky, Fabian; Padgett, William; Creveling, Cyrus R.; Daly, John W.; Kirk, Kenneth L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1972 - 1977
反应条件
in trifluoroacetic acid
Heating;
参考文献
Ladd, David L.; Gaitanopoulos, Dimitri; Weinstock, Joseph
Synthetic Communications, 1985 , vol. 15, p. 61 - 70
