7-氮杂吲哚-2-羧酸甲酯合成路线 (共 3 条)
反应条件
in methanol; hexanes; N,N-dimethyl-formamide
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: 56 percent / NaOMe / methanol / -10 - 0 °C 2: 25 percent / 1,3,5-trimethyl-benzene / 1 h / Heating View Scheme
参考文献
Roy, Patrick J.; Dufresne, Claude; Lachance, Nicolas; Leclerc, Jean-Philippe; Boisvert, Michel; Wang, Zhaoyin; Leblanc, Yves
Synthesis, 2005 , # 16 art. no. M03305SS, p. 2751 - 2757
反应条件
sulfuric acid; nitric acid
参考文献
IRONWOOD PHARMACEUTICALS INCORPORATED; LUDRIGAN, Regina; JEFFREY, John; MERMERIAN, Ara
Patent: WO2010/5528 A2, 2010 ;
Location in patent: Page/Page column 93 ;