8-乙烯-2-(甲基氧基)-1,5-萘啶合成路线 （共 5 条）
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=90°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/2047 A2, 2006 ;
Location in patent: Page/Page column 73-74 ;
反应条件
water; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
T=90°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/14580 A1, 2006 ;
Location in patent: Page/Page column 34 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=90°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/81289 A2, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=85°C; Suzuki Coupling;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2007/107965 A1, 2007 ;
Location in patent: Page/Page column 104 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=90°C;
参考文献
MORPHOCHEM AKTIENGESELLSCHAFT FUeR KOMBINATORISCHE CHEMIE
Patent: WO2006/21448 A1, 2006 ;
Location in patent: Page/Page column 29 ;
