1: 92 percent / triphenylphosphine; diethyl azodicarboxylate / CH2Cl2; toluene / 1 h / 20 °C 2: HCl / dioxane / 1 h / 20 °C 3: 80 percent / formic acid / H2O / 95 °C 4: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C 5: hydrogen / palladium on activated carbon / methanol 6: 2-methoxy-ethanol / 2 h / 115 °C 7: oxalyl chloride / CHCl3; dimethylformamide / Heating View Scheme
参考文献
Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 11 p. 829 - 843
1: nitric acid / dichloromethane; water / 2.5 h / -60 °C 2: oxalyl dichloride / N,N-dimethyl-formamide / 0 - 80 °C 3: hydrogenchloride / iron / ethanol; water / 3 h / 70 °C / Inert atmosphere View Scheme
参考文献
KING'S COLLEGE LONDON
Patent: US2012/149737 A1, 2012 ;