3,4-二甲氧基苯甲酸乙酯合成路线 （共 41 条）
反应条件
1: hydrogenchloride / ethanol / 3 h / 60 °C 2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide; dichloromethane / 20 °C 3: formic acid; [Ir(phenylpyridine(-1H))2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6); N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C / |Irradiation View Scheme
参考文献
Nguyen, John D.; Matsuura, Bryan S.; Stephenson, Corey R. J.
Journal of the American Chemical Society, 2014 , vol. 136, # 4 p. 1218 - 1221
反应条件
1: sodium tetrahydroborate / water; tetrahydrofuran / 20 °C 2: hydrogenchloride / ethanol / 3 h / 60 °C 3: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide; dichloromethane / 20 °C 4: formic acid; [Ir(phenylpyridine(-1H))2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6); N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C / |Irradiation View Scheme
参考文献
Nguyen, John D.; Matsuura, Bryan S.; Stephenson, Corey R. J.
Journal of the American Chemical Society, 2014 , vol. 136, # 4 p. 1218 - 1221
反应条件
1: water; KMnO4 / 80 - 90 °C 2: hydrogen chloride View Scheme
参考文献
Tiemann; Matsmoto
Chemische Berichte, 1876 , vol. 9, p. 939
Chemische Berichte, 1878 , vol. 11, p. 131
反应条件
hydrogenchloride in ethanol; water T=50 - 80°C; other object of study: stability in acidic solution; Product distribution;
参考文献
Shimizu; Osumi; Niimi; Nakagawa
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 3 A p. 334 - 341
参考文献
Butts, Craig P.; Eberson, Lennart; Hartshorn, Michael P.; Persson, Ola
Acta Chemica Scandinavica, 1997 , vol. 51, # 6-7 p. 718 - 732
反应条件
in ethanol; dichloromethane T=20°C; 3 h; Irradiationvarious solvents; the effect of ethanol, temperature, and time; Product distribution;
参考文献
Butts, Craig P.; Eberson, Lennart; Hartshorn, Michael P.; Persson, Ola
Acta Chemica Scandinavica, 1997 , vol. 51, # 6-7 p. 718 - 732
参考文献
Buck; Ide
Journal of the American Chemical Society, 1932 , vol. 54, p. 4359,4364
参考文献
Menozzi, Giulia; Merello, Luisa; Fossa, Paola; Mosti, Luisa; Piana, Antonietta; Mattioli, Francesca
Farmaco, 2003 , vol. 58, # 9 p. 795 - 808
反应条件
in toluene; acetonitrile
参考文献
Takeda Chemical Industries
Patent: US5747486 A1, 1998 ;
反应条件
sodium hydride in tetrahydrofuran T=20°C;
参考文献
Kim, Ikyon; Song, Jong Hwan; Park, Chang Min; Jeong, Joon Won; Kim, Hyung Rae; Ha, Jin Ryul; No, Zaesung; Hyun, Young-Lan; Cho, Young Sik; Sook Kang, Nam; Jeon, Dong Ju
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 922 - 926
