3,4-二甲氧基苯甲酸乙酯合成路线 （共 41 条）
反应条件
hydrazine hydrate 6 h; Heating;
参考文献
Husain, Asif; Ahmad, Ausaf; Alam; Ajmal; Ahuja, Priyanka
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3798 - 3804
反应条件
1: 1.) LDA, TMEDA / 1.) Et2O, 0 deg C, 3 h; room temperature, 40 h, 2.) CH2Cl2 2: 83 percent / 1 h / 160 °C / 3 Torr View Scheme
参考文献
Hua, Duy H.; Chen, Yi; Sin, Hong-Sig; Maroto, Maria J.; Robinson, Paul D.; Newell, Steven W.; Perchellet, Elisabeth M.; Ladesich, James B.; Freeman, Jonathan A.; Perchellet, Jean-Pierre; Chiang, Peter K.
Journal of Organic Chemistry, 1997 , vol. 62, # 20 p. 6888 - 6896
参考文献
Behal; Tiffeneau
Bulletin de la Societe Chimique de France, 1908 , vol. <4> 3, p. 730
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 332
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 5: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 6: trichlorophosphate / toluene / Reflux 7: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: With sodium hydroxide in water T=70°C; 2 h; 2: With hydrogenchloride in water T=20°C; pH=2 - 3; 1 h;
参考文献
Archiv der Pharmazie, , vol. 345, # 4 p. 287 - 293
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: acetic acid; nitric acid / 0 °C 2: hydrogen; palladium on activated charcoal / methanol 3: 165 - 170 °C 4: trichlorophosphate / toluene View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: sodium / 120 °C 2: aqueous hydriodic acid; acetic acid anhydride / 140 °C View Scheme
参考文献
Badhwar; Kang; Venkataraman
Journal of the Chemical Society, 1932 , p. 1107,1108
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -30 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: Dowex-H / isopropyl alcohol / Reflux View Scheme
参考文献
Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
