3,4-二甲氧基苯甲酸乙酯合成路线 （共 41 条）
反应条件
potassium hydroxide; hydroxylamine hydrochloride in methanol 36 h; Ambient temperature;
参考文献
Liguori, Angelo; Sindona, Giovanni; Romeo, Giovanni; Uccella, Nicola
Synthesis, 1987 , # 2 p. 168
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 5: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 5: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 6: trichlorophosphate / toluene / Reflux 7: pyridine / isopropyl alcohol / Reflux 8: water; sodium hydroxide / methanol View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: 77 percent / HONH2*HCl, KOH / methanol / 36 h / Ambient temperature 2: 94 percent / PBr3 / benzene / 5 h / Heating View Scheme
参考文献
Liguori, Angelo; Sindona, Giovanni; Romeo, Giovanni; Uccella, Nicola
Synthesis, 1987 , # 2 p. 168
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 5: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 6: trichlorophosphate / toluene / Reflux View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: hydrazine hydrate / ethanol 2: ethanol 3: sodium hydroxide View Scheme
参考文献
Abuo-Rahma, Gamal El-Din A.A.; Abdel-Aziz, Mohamed; Beshr, Eman A.M.; Ali, Taha F.S.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 185 - 198
反应条件
1.1: sodium hydroxide / water / 2 h / 70 °C
1.2: 1 h / 20 °C / pH 2 - 3
2.1: hydrogenchloride / 0.5 h / 20 °C
2.2: 14 h / 65 °C
2.3: 1 h / 20 °C
View Scheme
参考文献
Liu, Yajing; Zhang, Shulan; Li, Ye; Wang, Jianqiang; Song, Yu; Gong, Ping
Archiv der Pharmazie, 2012 , vol. 345, # 4 p. 287 - 293
反应条件
1: ethyl 3,4-dimethoxybenzoate With sodium hydride in tetrahydrofuran; dimethyl sulfoxide
T=10 - 15°C; Inert atmosphere;
2: 3-(3,4-dimethoxyphenyl)-5-(3-fluorophenyl)isoxazole in tetrahydrofuran; dimethyl sulfoxide
T=10 - 20°C; Inert atmosphere;
参考文献
LUDWIG-MAXIMILIANS-UNIVERSITAeT MUeNCHEN; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E. V.; GIESE, Armin; BERTSCH, Uwe; KRETZSCHMAR, Hans; HABECK, Mathias; HIRSCHBERGER, Thomas; TAVAN, Paul; GRIESINGER, Christian; LEONOV, Andrei; RYAZANOV, Sergey; WEBER, Petra
Patent: WO2010/372 A2, 2010 ;
Location in patent: Page/Page column 43-44 ;
