3,4-二羟基苯甲酸乙酯合成路线 （共 47 条）
参考文献
Tsuji, Koichi; Tsubouchi, Hidetsugu; Yasumura, Koichi; Matsumoto, Makoto; Ishikawa, Hiroshi
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2135 - 2149
反应条件
1: K2CO3*1.5H2O / acetone / 24 h / Heating 2: 1.93 g / NaOH / H2O; methanol / 3 h / Heating 3: oxalyl chloride; DMF / hexane; CH2Cl2 / 3 h / 0 °C View Scheme
参考文献
Gardner, Richard Andrew; Kinkade, Rebecca; Wang, Chaojie; Phanstiel IV, Otto
Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3530 - 3537
反应条件
1: 3,4-dihydroxy-benzoic acid ethyl ester With potassium carbonate in N,N-dimethyl-formamide 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; Bao, Rudi
Patent: US2009/111772 A1, 2009 ;
Location in patent: Page/Page column 67 ;
US 20090111772 A1
反应条件
1: caesium carbonate / N,N-dimethyl-formamide 2: NaOH; LiAlH4 / tetrahydrofuran; water View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: K2CO3 / cyclohexanone 2: aq. KOH / ethanol View Scheme
参考文献
Borisch, Konstanze; Diele, Siegmar; Goering, Petra; Kresse, Horst; Tschierske, Carsten
Journal of Materials Chemistry, 1998 , vol. 8, # 3 p. 529 - 543
反应条件
tri-n-butylammonium iodide; potassium carbonate in acetone Heating;
参考文献
Wissner, Allan; Brawner Floyd; Rabindran, Sridhar K.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Shen, Ru; Wang, Yu-Fen; Tsou, Hwei-Ru
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2893 - 2897
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4801705 A1, 1989 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20 - 80°C;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1.1: potassium carbonate / acetone / 0.5 h / 20 °C 1.2: 5 h / 50 °C 2.1: sodium hydroxide / water / 2 h / 70 °C 2.2: 1 h / 20 °C / pH 2 - 3 View Scheme
参考文献
Archiv der Pharmazie, , vol. 345, # 4 p. 287 - 293
反应条件
potassium carbonate in butanone 84 h; Heating;
参考文献
Journal of Materials Chemistry, , vol. 8, # 2 p. 331 - 341
