反应条件
1: 96 percent / imidazole / dimethylformamide / 1 h / 0 °C
2: 1.) BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, -78 deg C, 20 min
3: 90 percent / H2 / 5percent PdC / tetrahydrofuran; acetic acid / 21 h / 33602700 Torr / Ambient temperature
4: 89 percent / HOBT, DCC / tetrahydrofuran / 15 h / Ambient temperature
5: 73 percent / TBSOTf, 2,6-lutidine / CH2Cl2 / 2 h / 0 °C
6: DCC, HOBT / CH2Cl2 / 1.) -20 deg C, 30 min, 2.) 4 deg C, 40 h 78 percent
7: 78 percent / LiOH / H2O; tetrahydrofuran; methanol / 144 h / Ambient temperature
8: CMC, DMAP*TFA / CHCl3; tetrahydrofuran / 1.) 20 h, 2.) reflux, 1 h, 28 percent
View Scheme
