2,3,4,6-四-O-乙酰-β-D-吡喃葡萄糖合成路线 （共 199 条）
反应条件
1: 97 percent / 1,2,4-triazole / CH2Cl2 / 2 h / Ambient temperature 2: 98 percent / 30percent H2O2 / tetrahydrofuran / 1.5 h / Ambient temperature 3: H2, 10percent NaHCO3 / 5percent Pd/C / ethanol / 10 h / 760.2 Torr / Ambient temperature 4: 1N NaOH / 3 h / Ambient temperature View Scheme
参考文献
Sim, Mui Mui; Kondo, Hirosato; Wong, Chi-Huey
Journal of the American Chemical Society, 1993 , vol. 115, # 6 p. 2260 - 2267
反应条件
1.1: dichloromethane / 1 h / 0 °C / Inert atmosphere 1.2: 0.5 h / 0 °C / Inert atmosphere 2.1: boron trifluoride dimethyl etherate / dichloromethane / 20 °C / Inert atmosphere View Scheme
参考文献
METASIGNAL THERAPEUTICS INC.; SUPURAN, Claudiu; DEDHAR, Shoukat; CARTA, Fabrizio; WINUM, Jean-Yves; MCDONALD, Paul C; UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES; CNRS - DIRE
Patent: WO2012/70024 A1, 2012 ;
反应条件
Lawesson's reagent in 1,4-dioxane T=110°C; 72 h;
参考文献
Bernardes, Goncalo J. L.; Gamblin, David P.; Davis, Benjamin G.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 24 p. 4007 - 4011
反应条件
1.1: dichloromethane / 1 h / 0 °C / Inert atmosphere 1.2: 0.5 h / 0 °C / Inert atmosphere 2.1: boron trifluoride dimethyl etherate / dichloromethane / 20 °C / Inert atmosphere 3.1: methanol; sodium methylate / 0.5 h / 20 °C View Scheme
参考文献
METASIGNAL THERAPEUTICS INC.; SUPURAN, Claudiu; DEDHAR, Shoukat; CARTA, Fabrizio; WINUM, Jean-Yves; MCDONALD, Paul C; UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES; CNRS - DIRE
Patent: WO2012/70024 A1, 2012 ;
反应条件
pyridine hydrogenfluoride in acetone Ambient temperature;
参考文献
Szarek, Walter A.; Grynkiewicz, Grzegorz; Doboszewski, Bogdan; Hay, George W.
Chemistry Letters, 1984 , p. 1751 - 1754
反应条件
1-fluoro-2-methyl-N,N-diisopropyl-propenylamine in chloroform 6 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Miethchen, Ralf; Hager, Christian; Hein, Martin
Synthesis, 1997 , # 2 p. 159 - 161
参考文献
Ciba-Geigy Corporation
Patent: US5218097 A1, 1993 ;
反应条件
diethylamino-sulfur trifluoride in tetrahydrofuran Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Griffith, Marei H. E.; Hindsgaul, Ole
Carbohydrate Research, 1991 , vol. 211, # 1 p. 163 - 166
反应条件
in chloroform 6 h; Ambient temperature; Product distribution;
参考文献
Ernst, Beat.; Winkler, Tammo.
Tetrahedron Letters, 1989 , vol. 30, # 23 p. 3081 - 3084
反应条件
in chloroform 6 h; Ambient temperature; Product distribution;
参考文献
Ernst, Beat.; Winkler, Tammo.
Tetrahedron Letters, 1989 , vol. 30, # 23 p. 3081 - 3084
