(1R,2S,5S)-N-[3-氨基-1-(环丁基甲基)-2-羟基-3-氧代丙基]-3-[(2S)-2-[[[叔丁基氨基]羰基]氨基]-3,3-二甲基-1-氧代丁基]-6,6-二甲基-3-氮杂双环[3.1.0]己烷-2-甲酰胺合成路线 (共 2 条)
反应条件
1: With NaClO; sodium acetate; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical in tert-butyl methyl ether T=10 - 20°C; 2: With water; acetic acid in tert-butyl methyl ether 2.25 h; 3: With NaClO; ascorbic acid powder Product distribution / selectivity; more than 3 stages;
参考文献
Schering Corporation
Patent: US2007/149459 A1, 2007 ;
Location in patent: Page/Page column 6-7 ;
反应条件
Stage #1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 3 h; Stage #2: With hydrogenchloride; water in tetrahydrofuran Show Experimental Procedure
参考文献
SCHERING CORPORATION Patent: WO2006/130553 A2, 2006 ; Location in patent: Page/Page column 403 ;