4,6-二氯-3-硝基喹啉合成路线 （共 4 条）
反应条件
trichlorophosphate
T=120°C; 0.75 h;
参考文献
Kumar, Sanjay; Vishwakarma, Ram; Mundada, Ramswaroop; Deore, Vijaykumar; Kumar, Pramod; Sharma, Somesh
Patent: US2012/108627 A1, 2012 ;
Location in patent: Page/Page column 16 ;
反应条件
1.1: sodium hydroxide / water / 20 - 45 °C
1.2: 0 - 20 °C
2.1: potassium carbonate; acetic anhydride / 1 h / 90 °C
3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1 h / Reflux
View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
反应条件
1: potassium carbonate; acetic anhydride / 1 h / 90 °C
2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1 h / Reflux
View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
反应条件
1: acetic anhydride; potassium acetate / 3 h / 120 °C
2: trichlorophosphate / dichloromethane / 0.75 h / 120 °C
View Scheme
参考文献
Kumar, Sanjay; Vishwakarma, Ram; Mundada, Ramswaroop; Deore, Vijaykumar; Kumar, Pramod; Sharma, Somesh
Patent: US2012/108627 A1, 2012 ;
