2,4-二氯-5-氨基苯酚合成路线 （共 9 条）
反应条件
boron tribromide in dichloromethane T=20°C;
参考文献
Boschelli; Ye; Wang; Dutia; Johnson; Wu; Miller; Powell; Yaczko; Young; Tischler; Arndt; Discafani; Etienne; Gibbons; Grod; Lucas; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3965 - 3977
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
反应条件
1: glacial acetic acid; chlorine / 15 - 20 °C 2: hydrochloric acid View Scheme
参考文献
Jacobs; Heidelberger; Rolf
Journal of the American Chemical Society, 1919 , vol. 41, p. 460
反应条件
1: chlorine 2: hydrogenchloride / methanol; water / 2 h / 75 °C / |Inert atmosphere View Scheme
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
反应条件
hydrogenchloride; tin
参考文献
Musajo; Minchilli
Gazzetta Chimica Italiana, 1941 , vol. 71, p. 762,763 Anm.
Full Text Show Details
Musajo; Minchilli
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 301,306
Gazzetta Chimica Italiana, 1941 , vol. 71, p. 762,763 Anm.
参考文献
Ando, Iwao; Ohtsuka, Toshikazu; Miki, Nobuo; Takahashi, Toshio; Hayase, Yoshio; Hayashi, Yoshiyuki
Agricultural and Biological Chemistry, 1989 , vol. 53, # 7 p. 2001 - 2004
参考文献
Musajo; Minchilli
Gazzetta Chimica Italiana, 1941 , vol. 71, p. 762,763 Anm.
反应条件
1.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / |Inert atmosphere
1.2: 1 h / 0 - 65 °C
1.3: 1 h / 40 - 50 °C
2.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C
3.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C
View Scheme
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
反应条件
1.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / |Inert atmosphere
1.2: 1 h / 0 - 65 °C
1.3: 1 h / 40 - 50 °C
2.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C
3.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C
4.1: potassium hydroxide; potassium carbonate / water; acetone / 0.5 h / 60 - 65 °C
View Scheme
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
