1-(异氰基甲基)-4-甲基苯合成路线 （共 9 条）
反应条件
1,1-diphenylene; chlorobenzene in benzene T=170°C; also at 190, 210 and 230 deg C; ΔHY (excit.), ΔΔHY-H(excit.), ΔSY(excit.), ΔΔSY-H(excit); Rate constantThermodynamic data;
参考文献
Kim, Sung Soo; Choi, Won Jung; Zhu, Yu; Kim, Jin Hyun
Journal of Organic Chemistry, 1998 , vol. 63, # 4 p. 1185 - 1189
反应条件
1: NaH / dimethylformamide 2: (i) aq. HCl, MeOH, (ii) NaOH View Scheme
参考文献
Matsumoto,K. et al.
Journal of Organic Chemistry, 1973 , vol. 38, p. 2094 - 2096
反应条件
naphthalene T=0 - 40°C; Irradiationreactions under var. conditions; exit ΔH, exit ΔS; KineticsRate constant;
参考文献
Kim, Sung Soo; Kim, Hoon; Yang, Ki Woong
Tetrahedron Letters, 1997 , vol. 38, # 30 p. 5303 - 5306
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene T=80°C; 1 h; relative rates, Hammett correlations and secondary α-deuterium kinetic isotope effect for cyanide abstractions from title comp. by tri-n-butyltin radical;
参考文献
Kim, Sung Soo; Yang, Ki Woong; Lee, Chang Soo
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4827 - 4829
反应条件
naphthalene T=0 - 40°C; Irradiationreactions under var. conditions; exit ΔH, exit ΔS; KineticsRate constant;
参考文献
Kim, Sung Soo; Kim, Hoon; Yang, Ki Woong
Tetrahedron Letters, 1997 , vol. 38, # 30 p. 5303 - 5306
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
T=50°C; 3.5 h;
参考文献
Jacobsen, E. Jon; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; Im, Wha Bin; Sethy, Vimala H.; Tang, Andrew H.; Von Voigtlander, Philip F.; Petke, James D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3820 - 3836
反应条件
diisopropylamine; trichlorophosphate in dichloromethane
T=-30°C; Inert atmosphere;
参考文献
Buyck, Thomas; Wang, Qian; Zhu, Jieping
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12714 - 12718
Angew. Chem., 2013 , vol. 125, # 48 p. 12946 - 12950,5
反应条件
1: water / 125 °C / |Microwave irradiation; |Inert atmosphere
2: diisopropylamine; trichlorophosphate / dichloromethane / -30 °C / |Inert atmosphere
View Scheme
参考文献
Buyck, Thomas; Wang, Qian; Zhu, Jieping
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12714 - 12718
Angew. Chem., 2013 , vol. 125, # 48 p. 12946 - 12950,5
反应条件
1: With sodium cyanide in ethanol
T=20°C; 0.333333 h;
2: With ammonia in methanol
T=100°C; 15 h; resealable tube;
3: With tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C;
参考文献
Allergan, Inc.
Patent: US2005/59721 A1, 2005 ;
Location in patent: Page/Page column 9 ;
