5-溴-2,4-二甲氧基苯甲酸甲酯合成路线 (共 10 条)
反应条件
hydrogenchloride in methanol T=0°C; 14 h; Reflux;
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION; SANTOS, Webster, L.; LYNCH, Kevin, R.; MACDONALD, Timothy, L.; KENNEDY, Andrew; KHAREL, Yugesh; RAJE, Mithun, Rajendra; HOUCK, Joseph
Patent: WO2013/119946 A1, 2013 ;
Location in patent: Paragraph 0311; 0204 ;
反应条件
sulfuric acid T=70°C; 5 h;
参考文献
Japan Tobacco, Inc.
Patent: EP1992607 A1, 2008 ;
Location in patent: Page/Page column 79-80 ;
反应条件
potassium carbonate in acetone Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44045 A1, 2008 ;
Location in patent: Page/Page column 314 ;
WO 2008/044045 A1
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in water; acetone
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US5686482 A1, 1997 ;
反应条件
tetrabutylammomium bromide; 3,3-dimethyldioxirane in acetone T=0°C; regioselective reaction;
参考文献
Lee, Yean-Jang; Wu, Huan-Ting; Lin, Chia-Ning
Letters in Organic Chemistry, 2009 , vol. 6, # 7 p. 585 - 587
反应条件
1: glacial acetic acid / 30 - 35 °C / durch Bromierung 2: NaOH-solution / 60 - 70 °C 3: sulfuric acid View Scheme
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127
反应条件
1: NaOH-solution / 60 - 70 °C 2: sulfuric acid View Scheme
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127