5-溴-2-羟基-4-甲基苯甲酸甲酯合成路线 （共 4 条）
反应条件
bromine in chloroform
T=0°C; 1 h;
参考文献
GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James
Patent: WO2012/28629 A1, 2012 ;
Location in patent: Page/Page column 27 ;
WO 2012/028629 A1
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide
T=40°C;
参考文献
Guo, Wei; Li, Junfei; Fan, Ningjuan; Wu, Weiwei; Zhou, Peiwen; Xia, Chizhong
Synthetic Communications, 2005 , vol. 35, # 1 p. 145 - 152
反应条件
1: thionyl chloride / 24 h / 50 °C
2: bromine / chloroform / 1 h / 0 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James
Patent: WO2012/28629 A1, 2012 ;
WO 2012/028629 A1
反应条件
methanol; sodium methylate
参考文献
v. Walther; Zipper
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 91, p. 388
