甲基5-溴-2-甲氧基-4-甲基-苯甲酸酯合成路线 （共 8 条）
反应条件
bromine; acetic acid
T=20 - 25°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO KG
Patent: WO2004/108673 A2, 2004 ;
Location in patent: Page 47-49 ;
反应条件
1: aq. NaOH
2: aq. NaOCl
3: H2SO4
4: Br2 / acetic acid
View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: AlCl3 / 165 °C
2: aq. NaOH
3: aq. NaOCl
4: H2SO4
5: Br2 / acetic acid
View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: aq. NaOCl
2: H2SO4
3: Br2 / acetic acid
View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: H2SO4
2: Br2 / acetic acid
View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: potassium carbonate / acetone / 5 h / 50 °C
2: bromine / chloroform / 1.08 h / 0 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James
Patent: WO2012/28629 A1, 2012 ;
WO 2012/028629 A1
反应条件
methanol; sodium methylate
参考文献
v. Walther; Zipper
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 91, p. 388
反应条件
1: With sodium hydroxide in ethanol; water
0.5 h; Heating / reflux;
2: With hydrogenchloride in water
pH=2;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO KG
Patent: WO2004/108673 A2, 2004 ;
Location in patent: Page 47-49 ;
