1: With potassium hydroxide in methanol T=50°C; 12 h; 2: With hydrogenchloride in water

1: aq. KOH / ethanol 2: 2,6-di-tert-butyl-4-methylphenol / N,N-dimethyl-acetamide; dioxane / 60 °C View Scheme

1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane; diethyl ether / 20 °C / |Inert atmosphere 2: (N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)CuOtBu; 1,1,3,3-tetramethyldisiloxane; cesium fluoride / 1,4-dioxane / 24 h / 0 - 25 °C / |Inert atmosphere View Scheme