1-苄基-3-氧杂-4-哌啶甲酸乙酯合成路线 （共 20 条）
反应条件
sodium hydrogencarbonate in diethyl ether; water 1 h;
参考文献
PFIZER INC.
Patent: WO2008/120093 A1, 2008 ;
Location in patent: Page/Page column 74-75 ;
反应条件
sodium ethanolate; toluene
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
反应条件
1.1: triethylamine / toluene; 1,4-dioxane / 5.17 h / 95 °C / |Inert atmosphere; |Reflux; |Large scale 2.1: sodium ethanolate / toluene / 90 - 100 °C / |Inert atmosphere; |Large scale 2.2: 0.17 h / 5 - 10 °C / |Large scale View Scheme
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
反应条件
hydrogenchloride; water
参考文献
Iselin; Hoffmann
Helvetica Chimica Acta, 1954 , vol. 37, p. 178,183
反应条件
hydrogenchloride in ethanol T=22°C; 0.5 h; Inert atmosphereLarge scale;
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
反应条件
1: sodium methylate / methanol / 96 h / 0 - 60 °C / |Inert atmosphere 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 130 °C 3: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 16.25 h / 0 - 20 °C 4: triethylamine / dichloromethane / 16 h / 0 - 20 °C View Scheme
参考文献
ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David
Patent: WO2014/15291 A1, 2014 ;
反应条件
1: ethyl-3-oxo-1-phenylmethyl-4-piperidinecarboxylate With hydrogen; palladium 10 on activated carbon in ethanol 16 h; 2: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 16 h;
参考文献
NOVARTIS AG; MILLER-MOSLIN, Karen; TOURE, Bakary-Barry; VISSER, Michael Scott; YUSUFF, Naeem
Patent: WO2011/29842 A1, 2011 ;
Location in patent: Page/Page column 40 ;
WO 2011/029842 A1
反应条件
1: H2 / Pd/C / ethanol; H2O / 20 °C / 2585.74 Torr 2: aq. NaHCO3; NaCl / CHCl3 / 60 °C View Scheme
参考文献
BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian T.; CONLON, Patrick; CHAN, Timothy R.; JENKINS, Tracy J.; CAI, Xiongwei; HUMORA, Michael; SHI, Xianglin; MILLER, Ross A.; THOMPSON, Andrew
Patent: WO2013/185084 A1, 2013 ;
反应条件
sodium methylate in methanol T=0 - 60°C; 96 h; Inert atmosphere;
参考文献
ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David
Patent: WO2014/15291 A1, 2014 ;
Location in patent: Page/Page column 174; 175 ;
反应条件
1: With sodium methylate in methanol T=20°C; 20 h; 2: With acetic acid in methanol T=10°C; 1 h;
参考文献
WO2005/42537 A1, ;
Page/Page column 85 ;
WO 2005/042537 A1
