ALPHA-氨基苯并[1,3]二氧戊环-5-乙酸合成路线 （共 7 条）
反应条件
sodium hydroxide; hydrazine hydrate; palladium on activated charcoal in water Hydrogenolysis; 10 h; Heating;
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
barium dihydroxide in water 18 h; Heating;
参考文献
Boehme, E. H. W.; Bambury, R. E.; Baumann, R. J.; Erickson, R. C.; Harrison, B. L.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 405 - 412
反应条件
1: Na2S2O5 / methanol; H2O / 2 h / 35 °C 2: 90 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C 3: 82 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 4: 86 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Boehme, E. H. W.; Bambury, R. E.; Baumann, R. J.; Erickson, R. C.; Harrison, B. L.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 405 - 412
反应条件
1: 90 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C 2: 82 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 3: 86 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 82 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 2: 86 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
ammonia durch Erhitzen mit verd. Salzsaeure;
参考文献
Lorenz
Chemische Berichte, 1881 , vol. 14, p. 792
反应条件
acetic acid; sodium nitrite T=65°C; 4 h;
参考文献
Boehme, E. H. W.; Bambury, R. E.; Baumann, R. J.; Erickson, R. C.; Harrison, B. L.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 405 - 412
