2-氨基-4-甲基苯甲酰胺合成路线 （共 19 条）
反应条件
1: 6 h / 100 °C 2: acetic acid; bromine / methanol / 5 h / 20 °C View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
反应条件
1: aqueous acetic acid 2: aqueous HCl 3: POCl3; PCl5 View Scheme
参考文献
Curd et al.
Journal of the Chemical Society, 1948 , p. 1759,1765
参考文献
Niementowski
Chemische Berichte, 1888 , vol. 21, p. 1539
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 15
反应条件
Behandeln mit Wasser;
参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 12
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 50 ;
反应条件
T=110°C; 4 h; Sealed tube;
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
Location in patent: Paragraph 0438; 0439 ;
反应条件
1: 6 h / 100 °C
2: acetic acid; bromine / methanol / 5 h / 20 °C
3: sulfuric acid; potassium nitrate / 0.33 h / 80 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
反应条件
1: aqueous acetic acid
2: aqueous HCl
View Scheme
参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1895 , vol. <2> 51, p. 511
参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 12
