2,4-二氯吡啶并[3,2-d]嘧啶合成路线 （共 10 条）
反应条件
pyridine; trichlorophosphate T=180°C; P=150.015 - 900.09 Torr; 2 h; Neat (no solvent);
参考文献
Sun, Zhihua; Wang, Han; Wen, Kun; Li, Ya; Fan, Erkang
Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 4149 - 4153
反应条件
1: 190 °C 2: triethylamine; POCl3 View Scheme
参考文献
Ren, Pingda; Liu, Yi; Li, Liansheng; Chan, Katrina; Wilson, Troy Edward; Castro, Alfredo C.; Evans, Catherine A.; Snyder, Daniel A.
Patent: US2012/122838 A1, 2012 ;
反应条件
1: 190 °C 2: POCl3; PCl5 View Scheme
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1956 , vol. 78, p. 973,974
反应条件
1: 100 percent / AlCl3 / methoxybenzene / 2 h / 20 °C 2: 58 percent / POCl3; PCl5 / 4 h / Heating View Scheme
参考文献
Tikad, Abdellatif; Routier, Sylvain; Akssira, Mohamed; Leger, Jean-Michel; Jarry, Christian; Guillaume, Gerald
Synlett, 2006 , # 12 p. 1938 - 1942
反应条件
1: 72 percent / 48 h / Heating 2: Et3N / tetrahydrofuran / 1.5 h / -10 °C 3: NaN3 / tetrahydrofuran; H2O / 1.5 h / 0 °C 4: toluene / 2 h / Heating 5: pyridine / toluene / 24 h / Heating 6: 100 percent / AlCl3 / methoxybenzene / 2 h / 20 °C 7: 58 percent / POCl3; PCl5 / 4 h / Heating View Scheme
参考文献
Tikad, Abdellatif; Routier, Sylvain; Akssira, Mohamed; Leger, Jean-Michel; Jarry, Christian; Guillaume, Gerald
Synlett, 2006 , # 12 p. 1938 - 1942
反应条件
1: Et3N / tetrahydrofuran / 1.5 h / -10 °C 2: NaN3 / tetrahydrofuran; H2O / 1.5 h / 0 °C 3: toluene / 2 h / Heating 4: pyridine / toluene / 24 h / Heating 5: 100 percent / AlCl3 / methoxybenzene / 2 h / 20 °C 6: 58 percent / POCl3; PCl5 / 4 h / Heating View Scheme
参考文献
Tikad, Abdellatif; Routier, Sylvain; Akssira, Mohamed; Leger, Jean-Michel; Jarry, Christian; Guillaume, Gerald
Synlett, 2006 , # 12 p. 1938 - 1942
反应条件
1: pyridine / toluene / 24 h / Heating 2: 100 percent / AlCl3 / methoxybenzene / 2 h / 20 °C 3: 58 percent / POCl3; PCl5 / 4 h / Heating View Scheme
参考文献
Tikad, Abdellatif; Routier, Sylvain; Akssira, Mohamed; Leger, Jean-Michel; Jarry, Christian; Guillaume, Gerald
Synlett, 2006 , # 12 p. 1938 - 1942
反应条件
1: dioxane / beim Erwaermen des erhaltenen Bis-thiouronium-Salzes mit H2O 2: water; NH3 3: Raney nickel; ethanol; water; NH3 4: aqueous HCl View Scheme
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1956 , vol. 78, p. 973,974
反应条件
ethanol; platinum Hydrogenation;
参考文献
Oakes et al.
Journal of the Chemical Society, 1956 , p. 1045,1053
反应条件
tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0) in toluene
T=100°C; 1 h;
参考文献
Tikad, Abdellatif; Routier, Sylvain; Akssira, Mohamed; Leger, Jean-Michel; Jarry, Christian; Guillaumet, Gerald
Synthesis, 2009 , # 14 art. no. T02509SS, p. 2379 - 2384
