3-硝基亚苄基乙酰乙酸乙酯合成路线 （共 13 条）
反应条件
n-butyllithium; ammonium chloride in tetrahydrofuran; methanol; hexane; dichloromethane
参考文献
Bayer Aktiengesellschaft
Patent: US4703119 A1, 1987 ;
反应条件
in chloroform T=25°C; 0.5 h;
参考文献
Palacios, Francisco; Herran, Esther; Rubiales, Gloria; Alonso, Concepcion
Tetrahedron, 2007 , vol. 63, # 25 p. 5669 - 5676
反应条件
in ethanol 8 h; Heating;
参考文献
Meyer; Bossert; Wehinger; Stoepel; Vater
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 3 p. 407 - 409
反应条件
ammonium hydroxide in ethanol 24 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Raev; Ivanov
Archiv der Pharmazie, 1989 , vol. 322, # 5 p. 253 - 256
反应条件
ammonium hydroxide in ethanol 24 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Raev; Ivanov
Archiv der Pharmazie, 1989 , vol. 322, # 5 p. 253 - 256
反应条件
1: Et3N / butan-1-ol / 4 h / Heating
2: MnO2 / CHCl3 / 2 h / Heating
3: aq. NaOH / methanol / 10 h / Heating
4: SOCl2 / CH2Cl2; dimethylformamide / 1.5 h / 7 °C
5: CH2Cl2; dimethylformamide / 2 h
View Scheme
参考文献
Kuno; Sugiyama; Katsuta; Sakai; Takasugi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 9 p. 2423 - 2431
反应条件
in ethanol
48 h; Heating;
参考文献
Joslyn, Alan F.; Luchowski, Elizabeth; Triggle, David J.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1489 - 1492
反应条件
ammonium hydroxide in ethanol
24 h; Ambient temperature;
参考文献
Raev; Ivanov
Archiv der Pharmazie, 1989 , vol. 322, # 5 p. 253 - 256
反应条件
ammonium hydroxide in ethanol
24 h; Ambient temperature;
参考文献
Raev; Ivanov
Archiv der Pharmazie, 1989 , vol. 322, # 5 p. 253 - 256
反应条件
in ethanol
4 h; Heating;
参考文献
Kuno; Sugiyama; Katsuta; Kamitani; Takasugi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 6 p. 1452 - 1461
