反应条件
1: 4-Bromo-2-fluorobenzoic acid With thionyl chloride in benzene
12 h; RefluxInert atmosphere;
2: 1,2-dichloro-ethane With AlCl3, aluminium chloride
T=20°C; 2 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; HERTEL, Cornelia; KONKAR, Anish Ashok; KUEHNE, Holger; KUHN, Bernd; MAERKI, Hans P.; WANG, Haiyan
Patent: WO2012/101011 A2, 2012 ;
Location in patent: Page/Page column 53-54 ;