4-(2-吡啶基)-3-丁炔-1-醇合成路线 （共 4 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethanol T=20°C; 18 h;
参考文献
European Journal of Organic Chemistry, , # 2 p. 271 - 279
反应条件
copper(l) iodide; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); Tedicyp in N,N-dimethyl-formamide
T=100°C; 20 h;
参考文献
Lautens, Mark; Yoshida, Masahiro
Journal of Organic Chemistry, 2003 , vol. 68, # 3 p. 762 - 769
反应条件
1: 2-bromo-pyridine With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide
T=20°C;
2: ethynylmethyl carbinol With triethylamine
T=20 - 80°C; 20.5 h; Product distribution / selectivity;
参考文献
ADDEX PHARMACEUTICALS SA
Patent: WO2005/123703 A2, 2005 ;
Location in patent: Page/Page column 103-104 ;
WO 2005/123703 A2
反应条件
1: H2 / PtO2 / ethanol / 20 °C
2: oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Lin, Peter; Parikh, Mamta; Lo, Jane-Ling; Yang, Yi Tien; Cheng, Kang; Smith, Roy G; Fisher, Michael H; Wyvratt, Matthew J; Goulet, Mark T
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 8 p. 1077 - 1080
