2,4-二氯-8-甲基喹唑啉合成路线 （共 4 条）
反应条件
ammonia; zinc in dichloromethane; water 5 h; Reflux;
参考文献
Carna Biosciences Inc.; Crystalgenomics, Inc.
Patent: EP2226315 A1, 2010 ;
Location in patent: Page/Page column 18 ;
参考文献
SmithKline Beecham Intercredit B.V.
Patent: EP322133 B1, 1991 ;
Title/Abstract Full Text Show Details
SmithKline Beecham Intercredit B.V.
Patent: EP322133 A1, 1989 ;
反应条件
1: aq. AcOH / 2 h
2: POCl3, N,N-dimethylaniline / 5 h / Heating
View Scheme
参考文献
Ife, Robert J.; Brown, Thomas H.; Blurton, Peter; Keeling, David J.; Leach, Colin A.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2763 - 2773
参考文献
Juergens
Chemische Berichte, 1907 , vol. 40, p. 4413
