1-(4-甲基苯基)哌嗪合成路线 （共 31 条）
参考文献
Agarwal; Misra; Satsangi; Tiwari
Archiv der Pharmazie, 1982 , vol. 315, # 2 p. 142 - 146
反应条件
in water
T=50 - 60°C; 0.5 h;
参考文献
Schroth, W.; Kluge, H.; Frach, R.; Hodek, W.; Schaedler, H. D.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 5 p. 787 - 802
反应条件
1: 55 percent / H2O / 0.5 h / 50 - 60 °C
2: 55 percent / 50 percent aq. NaOH, triethylamine / CHCl3 / 40 - 50 °C
View Scheme
参考文献
Schroth, W.; Kluge, H.; Frach, R.; Hodek, W.; Schaedler, H. D.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 5 p. 787 - 802
反应条件
1: 75 percent / 48 h / 120 - 140 °C
2: 85 percent / hydrazin hydrate (98 percent) / Raney nickel / dimethylformamide / 10 h / Heating
View Scheme
参考文献
Agarwal, Jagdish C.; Gupta, Y. K.; Bhargava, K. P.; Shanker, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 512 - 514
参考文献
Samant, S. D.; Deodhar, K. D.; Kulkarni, R. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 3 p. 215 - 217
反应条件
1: 75 percent / 48 h / 120 - 140 °C
2: 85 percent / hydrazin hydrate (98 percent) / Raney nickel / dimethylformamide / 10 h / Heating
3: 65 percent / benzene / 8 h / Heating
View Scheme
参考文献
Agarwal, Jagdish C.; Gupta, Y. K.; Bhargava, K. P.; Shanker, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 512 - 514
反应条件
1: 75 percent / 48 h / 120 - 140 °C
2: 85 percent / hydrazin hydrate (98 percent) / Raney nickel / dimethylformamide / 10 h / Heating
3: 65 percent / benzene / 8 h / Heating
4: 55 percent / hydrazin hydrate (98 percent) / Pd-C (10 percent) / dimethylformamide / 12 h / Heating
View Scheme
参考文献
Agarwal, Jagdish C.; Gupta, Y. K.; Bhargava, K. P.; Shanker, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 512 - 514
反应条件
1: 65 percent / K2CO3 / acetone / Heating
2: 82 percent / 99.5percent hydrazine hydrate / Raney nickel / methanol / Heating
View Scheme
参考文献
Agarwal, Rajesh; Shukla, Mahesh K.; Satsangi, Rajiv K.; Chaudhary, Chapla
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 8 p. 680 - 682
反应条件
potassium hydroxide in diethyl ether; ethanol
参考文献
Rhone-Poulenc Sante
Patent: US4547504 A1, 1985 ;
反应条件
2: concentrated H2SO4
View Scheme
参考文献
Pollard et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 2989
