2,4-二氯-7-三氟甲基喹唑啉合成路线 （共 6 条）
反应条件
trichlorophosphate
T=105°C; 15 h; Inert atmosphere;
参考文献
Raynham, Tony Michael; Hammonds, Timothy Robin; Gilliatt, Julia Helen; Charles, Mark David; Pave, Gregoire Alexandre; Foxton, Caroline Heather; Carr, James Lindsay; Mistry, Neela Sumit
Patent: US2009/247519 A1, 2009 ;
Location in patent: Page/Page column 124 ;
反应条件
1: hydrogen bromide / Inert atmosphere
2: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr
3: 4 h / 160 - 180 °C / Inert atmosphere
4: phosphorus pentachloride; trichlorophosphate / 4 h / Reflux; Inert atmosphere
View Scheme
参考文献
Suez, Gal; Bloch, Victoria; Nisnevich, Gennady; Gandelman, Mark
European Journal of Organic Chemistry, 2012 , # 11 p. 2118 - 2122
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr
2: 4 h / 160 - 180 °C / Inert atmosphere
3: phosphorus pentachloride; trichlorophosphate / 4 h / Reflux; Inert atmosphere
View Scheme
参考文献
Suez, Gal; Bloch, Victoria; Nisnevich, Gennady; Gandelman, Mark
European Journal of Organic Chemistry, 2012 , # 11 p. 2118 - 2122
反应条件
T=175°C; Erhitzen des Reaktionsprodukts mit PCl5 und POCl3;
参考文献
BASF
Patent: DE1001439 , 1957 ;
Full Text Show Details
BASF
Patent: US2792397 , 1955 ;
反应条件
1: 1 h / 200 °C
2: trichlorophosphate; phosphorus pentachloride / 4 h / |Reflux; |Inert atmosphere
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参考文献
Yang, Ting; Zhuang, Hao; Lin, Xichen; Xiang, Jia-Ning; Elliott, John D.; Liu, Lianghui; Ren, Feng
Tetrahedron Letters, 2013 , vol. 54, # 32 p. 4159 - 4163
参考文献
BASF
Patent: DE1001439 , 1957 ;
Full Text Show Details
BASF
Patent: US2792397 , 1955 ;
