1H-吡咯-2,5-二甲醛合成路线 （共 22 条）
反应条件
1: H2 / 95 °C
2: NaOH / ethanol / 1.5 h / Heating
View Scheme
参考文献
Bergman, Jan; Renstroem, Lars; Sjoeberg, Birger
Tetrahedron, 1980 , vol. 36, p. 2505 - 2512
反应条件
sodium hydroxide
2 h; Heating;
参考文献
Miller, Raya; Olsson, Kjell
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1981 , vol. 35, # 4 p. 303 - 304
反应条件
1.1: 95.3 g / Et2NH / toluene / Heating
2.1: POCl3 / 1,2-dichloro-ethane / 0 - 5 °C
2.2: 1,2-dichloro-ethane / Heating
2.3: NaOAc*3H2O / 1,2-dichloro-ethane; H2O / Heating
3.1: 39.5 g / aq. NaOH / 3 h / Heating
View Scheme
参考文献
Knizhnikov; Borisova; Yurashevich; Popova; Chernyad'ev; Zubreichuk; Reshetova
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 6 p. 855 - 860
反应条件
1.1: POCl3 / 1,2-dichloro-ethane / 0 - 5 °C
1.2: 1,2-dichloro-ethane / Heating
1.3: NaOAc*3H2O / 1,2-dichloro-ethane; H2O / Heating
2.1: 39.5 g / aq. NaOH / 3 h / Heating
View Scheme
参考文献
Knizhnikov; Borisova; Yurashevich; Popova; Chernyad'ev; Zubreichuk; Reshetova
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 6 p. 855 - 860
反应条件
1: 80 percent / HgO, aq. HBF4 / dimethylsulfoxide / 2 h / 60 °C
2: 81 percent / KOH / ethanol / 5 h / 50 °C
View Scheme
参考文献
Cadamuro, Silvano; Degani, Iacopo; Fochi, Rita; Gatti, Antonella; Piscopo, Laura
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 23 p. 2939 - 2944
反应条件
sodium acetate
1) from -78 deg C to RT; 2) water, 15 h, reflux; Yield given. Multistep reaction;
参考文献
Bray, Brian L.; Hess, Petr; Muchowski, Joseph M.; Scheller, Markus E.
Helvetica Chimica Acta, 1988 , vol. 71, p. 2053 - 2057
反应条件
sodium hydroxide
3 h; Heating;
参考文献
Knizhnikov; Borisova; Yurashevich; Popova; Chernyad'ev; Zubreichuk; Reshetova
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 6 p. 855 - 860
反应条件
tert.-butyl lithium; sodium acetate
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Berthiaume, Sylvie L.; Bray, Brian L.; Hess, Petr; Liu, Yanzhou; Maddox, Michael L.; et al.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 675 - 684
反应条件
sodium tetrahydroborate in methanol
T=0°C; 0.25 h; Inert atmosphere;
参考文献
Sudhakar, Gangarajula; Kadam, Vilas D.; Bayya, Shruthi; Pranitha, Gavinolla; Jagadeesh, Bharatam
Organic Letters, 2011 , vol. 13, # 20 p. 5452 - 5455
反应条件
1: 50 percent / NaOH / acetonitrile / Heating
2: 90 percent / NaBH4 / methanol / 0 °C
3: 85 percent / Ag2O / acetonitrile / Heating
View Scheme
参考文献
Chin, Young-Won; Lim, Song Won; Kim, Seok-Ho; Shin, Dong-Yun; Suh, Young-Ger; Kim, Yang-Bae; Kim, Young Choong; Kim, Jinwoong
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 79 - 81
