N-苄氧羰基-L-己氨酸合成路线 （共 14 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran
参考文献
Thanigaimalai, Pillaiyar; Konno, Sho; Yamamoto, Takehito; Koiwai, Yuji; Taguchi, Akihiro; Takayama, Kentaro; Yakushiji, Fumika; Akaji, Kenichi; Kiso, Yoshiaki; Kawasaki, Yuko; Chen, Shen-En; Naser-Tavakolian, Aurash; Schoen, Arne; Freire, Ernesto; Hayashi, Yoshio
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 436 - 447
反应条件
antibody 7G12; Tris buffer; water in dimethyl sulfoxide T=25°C; Rate constant;
参考文献
Tanaka, Fujie; Kinoshita, Keiko; Tanimura, Ryuji; Fujii, Ikuo
Journal of the American Chemical Society, 1996 , vol. 118, # 10 p. 2332 - 2339
反应条件
potassium hydrogensulfate in diethyl ether; water
参考文献
Hudecz, Ferenc; Szekerke, Maria
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 1 p. 103 - 113
反应条件
1: 1,4-dioxane 2: triethylamine 3: lithium hydroxide hydrate; water / tetrahydrofuran View Scheme
参考文献
Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Tiew, Kok-Chuan; Uy, Roxanne Adeline Z.; Prior, Allan M.; Alliston, Kevin R.; Hua, Duy H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 62 - 65
反应条件
1: triethylamine 2: lithium hydroxide hydrate; water / tetrahydrofuran View Scheme
参考文献
Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Tiew, Kok-Chuan; Uy, Roxanne Adeline Z.; Prior, Allan M.; Alliston, Kevin R.; Hua, Duy H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 62 - 65
反应条件
1: triethylamine / dichloromethane / 2.08 h / 0 - 20 °C 2: lithium hydroxide hydrate / tetrahydrofuran; water / 3 h / 20 °C View Scheme
参考文献
Thanigaimalai, Pillaiyar; Konno, Sho; Yamamoto, Takehito; Koiwai, Yuji; Taguchi, Akihiro; Takayama, Kentaro; Yakushiji, Fumika; Akaji, Kenichi; Kiso, Yoshiaki; Kawasaki, Yuko; Chen, Shen-En; Naser-Tavakolian, Aurash; Schoen, Arne; Freire, Ernesto; Hayashi, Yoshio
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 436 - 447
反应条件
1: triethylamine / dichloromethane / 2.08 h / 0 - 20 °C 2: lithium hydroxide hydrate / tetrahydrofuran; water / 3 h / 20 °C View Scheme
参考文献
Thanigaimalai, Pillaiyar; Konno, Sho; Yamamoto, Takehito; Koiwai, Yuji; Taguchi, Akihiro; Takayama, Kentaro; Yakushiji, Fumika; Akaji, Kenichi; Kiso, Yoshiaki; Kawasaki, Yuko; Chen, Shen-En; Naser-Tavakolian, Aurash; Schoen, Arne; Freire, Ernesto; Hayashi, Yoshio
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 436 - 447
反应条件
2: 1.) BF3*Et2O; 2.) Zn/AcOH; 3.) Na2CO3; 4.) HIO4, RuCl3*3H2O / 1.) toluene, -78 deg C, 30 min; 2.) water, 40 deg C, 2 h; 3.) THF, water, r.t., 12 h; 4.) CCl4, CH3CN, water, 50 deg C, 24 h View Scheme
参考文献
Moody, Christopher J.; Lightfoot, Andrew P.; Gallagher, Peter T.
Synlett, 1997 , vol. 1997, # 6 p. 659 - 660
反应条件
sodium hydroxide; benzyl chloroformate
参考文献
Izumiya et al.
Nippon Kagaku Zasshi, 1958 , vol. 79, p. 420,423
Chem.Abstr., 1960 , p. 4408
反应条件
ruthenium trichloride; boron trifluoride diethyl etherate; sodium carbonate; acetic acid; periodic acid; zinc 1.) toluene, -78 deg C, 30 min; 2.) water, 40 deg C, 2 h; 3.) THF, water, r.t., 12 h; 4.) CCl4, CH3CN, water, 50 deg C, 24 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Moody, Christopher J.; Lightfoot, Andrew P.; Gallagher, Peter T.
Synlett, 1997 , vol. 1997, # 6 p. 659 - 660
