N-苄氧羰基-N-甲基甘氨酸合成路线 （共 19 条）
反应条件
sodium carbonate in 1,4-dioxane; water T=20°C;
参考文献
Lai, Michelle Y.H.; Brimble, Margaret A.; Callis, David J.; Harris, Paul W.R.; Levi, Mark S.; Sieg, Frank
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 533 - 548
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 3 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=~ 5;
参考文献
JANSSEN PHARMACEUTICA NV; LANTER, James, C.; MARKOTAN, Thomas, P.; SUBASINGHE, Nalin; SUI, Zhihua
Patent: WO2011/159854 A1, 2011 ;
Location in patent: Page/Page column 136 ;
WO 2011/159854 A1
参考文献
Beecham Group p.l.c.
Patent: US4609547 A1, 1986 ;
反应条件
triethylamine in water; acetonitrile T=20°C; 96 h;
参考文献
Negom Kouodom, Morelle; Ronconi, Luca; Celegato, Marta; Nardon, Chiara; Marchio, Luciano; Dou, Q. Ping; Aldinucci, Donatella; Formaggio, Fernando; Fregona, Dolores
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2212 - 2226
反应条件
triethylsilane; toluene-4-sulfonic acid; trifluoroacetic acid; paraformaldehyde in chloroform; benzene
参考文献
Merck and Co. Inc.
Patent: US4535167 A1, 1985 ;
反应条件
hydrogenchloride in sodium hydroxide; water; ethyl acetate
参考文献
Ortho Pharmaceutical Corporation
Patent: US4250086 A1, 1981 ;
反应条件
hydrogenchloride in 2-N sodium hydroxide
参考文献
Hoffmann-La Roche Inc.
Patent: US4250085 A1, 1981 ;
反应条件
sodium hydroxide; benzyl chloroformate
参考文献
Ben-Ishai; Katchalski
Journal of the American Chemical Society, 1952 , vol. 74, p. 3688
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Ames et al.
Journal of the Chemical Society, 1956 , p. 1984,1988
Full Text Show Details
Elmore
Journal of the Chemical Society, 1959 , p. 3152,3155
反应条件
triethylsilane in chloroform; trifluoroacetic acid T=20°C; 26 h;
参考文献
Hughes, Andrew B.; Sleebs, Brad E.
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2611 - 2637
反应条件
1.1: sodium hydrogencarbonate / ethyl acetate; water / 0 - 20 °C 2.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 3 h / 20 °C 2.2: pH ~ 5 View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; LANTER, James, C.; MARKOTAN, Thomas, P.; SUBASINGHE, Nalin; SUI, Zhihua
Patent: WO2011/159854 A1, 2011 ;
WO 2011/159854 A1
