potassium hydrogencarbonate in dichloromethane T=19 - 25°C; Large scale;

1: phenylphosphoric acid dichloride; alanine isopropyl ester hydrochloride With 1-methyl-1H-imidazole in dichloromethane T=-5 - 5°C; 1.5 h; 2: β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine in dichloromethane T=0 - 20°C; 5 h; ConcentrationTemperatureTime;

1: pentafluorophenyl phosphorodichloridate With triethylamine; phenol in dichloromethane T=20°C; 0.5 h; 2: alanine isopropyl ester hydrochloride With triethylamine in dichloromethane T=0°C; 1 h;

1: alanine isopropyl ester hydrochloride With triethylamine in dichloromethane T=-70°C; 0.25 h; 2: phenylphosphoric acid dichloride in dichloromethane T=-70 - 0°C; 4.5 h; 3: 2,3,4,5,6-pentafluorophenol in dichloromethane T=0°C; 4.33333 h; optical yield given as percent de;

1.1: triethylamine / dichloromethane / 0.25 h / -70 °C 1.2: 4.5 h / -70 - 0 °C 1.3: 4.33 h / 0 °C 2.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / -5 - 20 °C 2.2: -5 - 5 °C View Scheme

1.1: 1-methyl-1H-imidazole / dichloromethane / 1.5 h / -5 - 5 °C 1.2: 5 h / 0 - 20 °C 2.1: hydrogenchloride / water; di-isopropyl ether / 72 h / 22 °C View Scheme

1: potassium hydrogencarbonate / dichloromethane / 19 - 25 °C / |Large scale 2: dichloromethane; toluene / 1.25 h / -25 - -20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209273', constants.ctx, '0')">thionyl chloride</a> <br />5&nbsp;h;&nbsp;&nbsp;Reflux;&nbsp;<br /> <br /> &nbsp;