2,6-二氯-4-甲基吡啶合成路线 （共 5 条）
反应条件
n-butyllithium 1) THF, -80 deg C, 30 min, 2) 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/24905 A1, 2009 ;
Location in patent: Page/Page column 73 ;
WO 2009/024905 A1
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=110°C; 3 h; Inert atmosphere;
参考文献
NIPPON SHINYAKU CO., LTD.
Patent: US2011/288065 A1, 2011 ;
Location in patent: Page/Page column 46 ;
US 20110288065 A1
反应条件
trichlorophosphate T=95°C;
参考文献
F2G LIMITED
Patent: US2011/9390 A1, 2011 ;
Location in patent: Page/Page column 19 ;
参考文献
Robison
Journal of the American Chemical Society, 1958 , vol. 80, p. 5481
反应条件
ammonia in water T=200°C; 10 h;
参考文献
LABORATOIRES SERONO SA
Patent: WO2009/27283 A1, 2009 ;
Location in patent: Page/Page column 66 ;
