5-氧代-1-苯基吡咯烷-3-羧酸合成路线 （共 10 条）
反应条件
in water T=110°C; 30 h; Sealed tube;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 161 ;
WO 2010/142801 A1
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1180513 A1, 2002 ;
Location in patent: Referential example 43 ;
EP 1180513 A1
反应条件
ethanol T=100°C; im Rohr und Kochen des Reaktionsprodukts mit konz. Kalilauge unter Zusatz von etwas Alkohol;
参考文献
Anschuetz; Reuter
Justus Liebigs Annalen der Chemie, 1889 , vol. 254, p. 135
参考文献
Gottlieb
Justus Liebigs Annalen der Chemie, 1851 , vol. 77, p. 288
参考文献
Justus Liebigs Annalen der Chemie, , vol. 77, p. 288
参考文献
Gottlieb
Justus Liebigs Annalen der Chemie, 1851 , vol. 77, p. 288
反应条件
1: 90.5 percent / conc. H2SO4 / CH2Cl2 / Heating
2: 95.5 percent / NaBH4, MeOH / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Astellas Pharma Inc.
Patent: WO2006/123725 A1, 2006 ;
Location in patent: Page/Page column 65 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
T=20°C; 168 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 163-164 ;
WO 2010/142801 A1
反应条件
sulfuric acid in dichloromethane
Heating;
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
反应条件
dicyclohexyl-carbodiimide; trifluoroacetic acid
参考文献
Buzas,F. et al.
Chimica Therapeutica, 1972 , vol. 7, p. 398 - 403
